History

The <mds_ies_db> was initially created as the MDS_IES_DB by Andre R. O. Calvanti in 2004 at Princeton University. At that time, the database contained 13 organisms, 29 different pairs of micronuclear and macronuclear genes, 440 MDS pairs, 392 IESs, and 361 pointer sequences. Since then, Next-Generation Sequencing has emerged and the whole macronuclear and micronuclear genomes of Oxytricha trifallax and Tetrahymena thermophila have been sequenced. In 2014, Jonathan Burns began to restructure and modernize the MDS_IES_DB as the <mds_ies_db> to incorporate the new genomes and to provide a convenient means of viewing the rearrangement data. The new database includes a variety of new features, such as a genome browser and chord diagrams. In addition, the <mds_ies_db> is ready to include rearrangement information for the genomes of other ciliate species. The database is currently supported by the USF Math-Bio Lab at University of South Florida and the Landweber lab at Princeton University.

Development of the <mds_ies_db> is funded by the National Institutes of Health (No. R01 GM109459).

If you have sequenced MAC and MIC genomes for other ciliate species, please contact Laura Landweber at lfl@princeton.edu.

Contributors

USF Math-Bio Lab

Nataša Jonoska, PhD
Professor, Department of Mathematics and Statistics
University of South Florida


Jonathan Burns, PhD
Postdoctoral Fellow
Department of Mathematics and Statistics
University of South Florida


Denys Kukushkin
Graduate Student
Department of Mathematics and Statistics
University of South Florida

Landweber Lab

Laura F. Landweber, PhD
Professor, Department of Ecology and Evolutionary Biology
Princeton University


Kelsi A. Lindblad
Graduate Student
Department of Quantitative and Computational Biology
Princeton University


Xiao Chen
Graduate Student
Department of Molecular Biology
Princeton University